Moto2 in the MotoGP Class

2008 – 125cc Grand Prix World championship

Redding left the CEV championship in 2008, being entered by team BLU:sens Aprilia in the 125cc Grand Prix World championship. Redding made a sensational start at the opening round of Qatar, by being the youngest ever rider in the 125cc class to qualify on the front row of the grid, in fourth place. He went on to take fifth place in the race setting the lap record for the 125cc class of 2'05.635 in the process. He was also on the front row in Spain.

On 22 June 2008 Redding became the youngest ever Grand Prix winner, aged 15 years and 170 days, when he won the 2008 British 125cc Grand Prix at Donington Park. Redding took the lead with six laps remaining after pressuring Andrea Iannone into pushing too hard and going off at Craner Curves. Redding held off Frenchman Mike de migleo and Spaniard Marc Márquez to win in only his eighth 125cc outing. He became the first British winner of a 125cc race since Chas Mortimer won the 1975 Spanish Grand Prix and the first British winner of a British motorcycle Grand Prix in the 125cc class since 1973, when Tommy Robb won at the1973 Isle of Man TT, which was then the British round of the world championship. He is also the first British rider ever to win a British round of any Grand Prix class since the British motorcycle Grand Prix moved to Donington Park in 1987. In the first ever two-wheeled race at the famous Indianapolis Motor Speedway in America, Redding secured 4th place, having been in that position when it started to rain due to Hurricane Ike and Red Flag brought the race to a premature end.
Redding also won Rookie of the Year for being the highest placed new rider, finishing the season in eleventh overall.

2009 – 125cc Grand Prix World championship
For the 2009 125cc Motorcycle Grand Prix season Redding rode a factory Aprilia machinery and remained with team BLU:sens Aprilia.
Scott has had a mixed season so far with mechanical issues and handling difficulties. He got on the podium at the 2009 British Grand Prix, his second career podium.

2010 – Moto2
Redding signed with new team Marc VDS Racing Team in the Moto2 600cc class for 2010, having grown too big to continue competing in the 125cc class. He struggled in the initial pre-season tests, but was more competitive in later ones. Redding struggled at the beginning of the season, but improved to finish fourth in the British Grand Prix atSilverstone and became the youngest rider ever to score a podium finish in the 250cc/Moto2 class by finishing third in Indianapolis.

At the San Marino Grand Prix in Misano, Redding was involved in an accident which resulted in the death of Japanese rider Shoya Tomizawa. After Tomizawa fell from his bike on the twelfth lap of the race, he was immediately hit by Redding and Alex de Angelis, who were unable to avoid him. Redding received ten stitches for a back laceration but escaped major injury.
On 29 September 2010, Redding signed a two year contract with Marc VDS, keeping him in Moto2 until 2012.